Crohn's disease is manifested by fissure ulcers, transmural inflammation with lymphocytes, and granulomata affecting any part of the gastrointestinal tract. There seems to be a genetic predisposition, conditioned perhaps by environmental factors and possibly a virus. The disease is characterized by spontaneous fistulae, internal and external, anal lesions, stricture formation, and healing by fibrosis. The presenting symptoms are intestinal and systemic (Table 2). Systemic manifestations, such as arthritis, skin lesions, episcleritis and uveitis, pericholangitis, hydronephrosis, renal stones, amyloidosis, arrested maturation, fever, and anemia occur as complications of the intestinal disease. Medical treatment is empirical and supportive. Surgical treatment is reserved for complications. The incidence of Crohn's disease seems to be increasing because our diagnostic techniques are improving, but our treatment is unsatisfactory.
克罗恩病表现为裂隙性溃疡、伴有淋巴细胞的透壁性炎症以及累及胃肠道任何部位的肉芽肿。似乎存在遗传易感性，可能由环境因素以及可能的病毒所诱发。该疾病的特征为自发形成内瘘和外瘘、肛门病变、狭窄形成以及通过纤维化愈合。其首发症状包括肠道症状和全身症状（表2）。全身表现，如关节炎、皮肤病变、巩膜外层炎和葡萄膜炎、胆管周围炎、肾积水、肾结石、淀粉样变性、发育停滞、发热和贫血等，均为肠道疾病的并发症。药物治疗是经验性的且具有支持性。手术治疗仅用于处理并发症。由于我们的诊断技术在提高，克罗恩病的发病率似乎在上升，但我们的治疗效果并不理想。
