Nakamura H, Kawasaki M, Higuchi Y, Takahashi S
Department of Otolaryngology, Niigata University School of Medicine, Japan.
Acta Otolaryngol. 1999;119(5):592-8. doi: 10.1080/00016489950180856.
The aspirin triad (nasal polyposis, asthma and sensitivity to aspirin) is a well-recognized clinical entity, also known as aspirin-induced asthma (AIA). The sinusitis associated with AIA is often difficult to treat and aggravates the asthmatic symptoms. In order to evaluate the surgical treatment of sinusitis in AIA, 22 patients who underwent sinus surgery were studied. Twenty patients (90.9%) got any relief of their asthma symptoms from sinus surgery. Postoperative pulmonary function test 1 year after surgery showed statistically significant improvement over the preoperative one. Three of 5 patients (60%) who used systemic steroids were able to eliminate or reduce their dosages. Also, 8 of 17 patients (47.1%) who were using inhaled topical steroids reduced their dosages and statistical analysis showed a significant difference in the doses of topical steroid used before and after surgery. Subjective evaluation of 20 patients (90.9%) indicated that the sinus surgery was effective for their asthma condition; showing from mild to marked improvement. For AIA patients aggravated by sinus disease, we recommend sinus surgery to improve the quality of life.
阿司匹林三联征（鼻息肉病、哮喘和对阿司匹林敏感）是一种广为人知的临床病症，也被称为阿司匹林诱发的哮喘（AIA）。与AIA相关的鼻窦炎往往难以治疗，且会加重哮喘症状。为了评估AIA患者鼻窦炎的手术治疗效果，对22例接受鼻窦手术的患者进行了研究。20例患者（90.9%）的哮喘症状通过鼻窦手术得到了缓解。术后1年的肺功能测试显示，与术前相比有统计学意义的改善。5例使用全身类固醇的患者中有3例（60%）能够停用或减少剂量。此外，17例使用吸入性局部类固醇的患者中有8例（47.1%）减少了剂量，统计学分析显示手术前后局部类固醇的使用剂量有显著差异。20例患者（90.9%）的主观评估表明，鼻窦手术对其哮喘病情有效，改善程度从轻度到显著不等。对于因鼻窦疾病而加重的AIA患者，我们建议进行鼻窦手术以提高生活质量。
