Madsen A L, Vorstrup S, Rubin P, Larsen J K, Hemmingsen R
Department of Psychiatry, Bispebjerg Hospital, Copenhagen, Denmark.
Acta Psychiatr Scand. 1999 Aug;100(2):119-25. doi: 10.1111/j.1600-0447.1999.tb10832.x.
The aim of this study was to examine the temporal stability of neurological abnormalities in first-episode schizophrenic patients, and to clarify the relationships between such abnormalities and psychopathology.
A total of 18 schizophrenic patients, 11 non-schizophrenic patients and 10 healthy volunteers were examined neurologically at first admission and 5 years later.
A significant increase in the number of neurological abnormalities was seen in schizophrenic patients with genetic predisposition and in patients with a non-remitting course of disease. Birth complications had an impact on the occurrence of neurological abnormalities at first admission.
The association between a deteriorating course of disease and neurological impairment supports the theory that any possible impairment of the brain in schizophrenia is aggravated during the first 5 years of disease.
本研究旨在探讨首发精神分裂症患者神经功能异常的时间稳定性，并阐明此类异常与精神病理学之间的关系。
共对18例精神分裂症患者、11例非精神分裂症患者和10名健康志愿者在首次入院时及5年后进行了神经学检查。
有遗传易感性的精神分裂症患者以及病情呈非缓解病程的患者，其神经功能异常的数量显著增加。出生并发症对首次入院时神经功能异常的发生有影响。
疾病恶化病程与神经功能损害之间的关联支持了以下理论，即精神分裂症患者大脑中任何可能的损害在疾病的前5年中会加重。
