Matsuda H, Shimoda H, Yamahara J, Yoshikawa M
Kyoto Pharmaceutical University, Japan.
Biol Pharm Bull. 1999 Aug;22(8):870-2. doi: 10.1248/bpb.22.870.
We examined the antiallergic effects of phyllodulcin, hydrangenol, and their 8-O-glucosides, and thunberginols A and F isolated from the processed leaves (Hydrangeae Dulcis Folium) and dried leaves of Hydrangea macrophylla SERINGE var. thunbergii MAKINO using the passive cutaneous anaphylaxis (PCA) reaction. With the exception of phyllodulcin, these constituents were found to significantly inhibit the PCA reaction. Although thunberginol A showed the most potent inhibitory effect, hydrangenol was considered to be the principal antiallergic component in the processed leaves, after taking into account their contents.
我们使用被动皮肤过敏反应（PCA），研究了从绣球花（Hydrangeae Dulcis Folium）的加工叶和干燥叶中分离得到的苯偶姻、氢化苯偶姻及其8 - O - 葡萄糖苷，以及山荷叶素A和F的抗过敏作用。除苯偶姻外，这些成分均被发现能显著抑制PCA反应。尽管山荷叶素A显示出最强的抑制作用，但考虑到它们的含量，氢化苯偶姻被认为是加工叶中的主要抗过敏成分。
