Yoshikawa M, Matsuda H, Shimoda H, Shimada H, Harada E, Naitoh Y, Miki A, Yamahara J, Murakami N
Kyoto Pharmaceutical University, Japan.
Chem Pharm Bull (Tokyo). 1996 Aug;44(8):1440-7. doi: 10.1248/cpb.44.1440.
Following the characterization of thunberginols A, B, and F, six bioactive principles, thunberginols C, D, and E, thunberginol G 3'-O-glucoside, (-)-hydrangenol 4'-O-glucoside, and (+)-hydrangenol 4'-O-glucoside, were isolated from Hydrangeae Dulcis Folium, the processed leaves of Hydrangea macrophylla SERINGE var. thunbergii MAKINO, together with four kaempferol and quercetin oligoglycosides. Their chemical structures have been determined on the basis of chemical and physicochemical evidence. Thunberginols C, D, E, and G and (-)-hydrangenol 4'-O-glucoside showed antiallergic activity in the in vitro bioassay using the Schultz-Dale reaction. These components also exhibited inhibitory activities on the histamine release from rat mast cells and on the histamine-induced contraction in isolated guinea pig tracheal chain. In addition, thunberginols C, D, E, and G showed antimicrobial activities against oral bacteria.
在对藤绣球醇A、B和F进行表征之后，从绣球花（Hydrangea macrophylla SERINGE var. thunbergii MAKINO）的加工叶片甜茶（Hydrangeae Dulcis Folium）中分离出6种生物活性成分，即藤绣球醇C、D和E、藤绣球醇G 3'-O-葡萄糖苷、(-)-水甘草醇4'-O-葡萄糖苷和(+)-水甘草醇4'-O-葡萄糖苷，以及4种山柰酚和槲皮素低聚糖苷。已根据化学和物理化学证据确定了它们的化学结构。藤绣球醇C、D、E和G以及(-)-水甘草醇4'-O-葡萄糖苷在使用舒尔茨-戴尔反应的体外生物测定中显示出抗过敏活性。这些成分还对大鼠肥大细胞释放组胺以及对离体豚鼠气管链中组胺诱导的收缩表现出抑制活性。此外，藤绣球醇C、D、E和G对口腔细菌显示出抗菌活性。
