Adali M, Inal-Erden M, Akalin A, Efe B
Department of Biochemistry, Osmangazi University, The School of Medicine, Eskişehir, Turkey.
Clin Biochem. 1999 Jul;32(5):363-7. doi: 10.1016/s0009-9120(99)00024-7.
The purpose of this study was to examine lipid peroxidation and antioxidant states during hyperthyroidism states and after given different treatments.
We examined 44 hyperthyroid patients and 19 euthyroid healthy controls. Patients were divided into three groups according to the treatment: Propylthiouracil (PTU) group, PTU + propranolol (PRP) group, PTU + PRP + vitamin E (vitE) group.
In the hyperthyroid patients plasma malondialdehyde (MDA) levels were significantly high as compared to the control group (p < 0,001). There was a significant decrease in the MDA levels post-treatment (p < 0.001 in the PTU + PRP group and PTU + PRP + vitE group, p < 0.01 in the PTU group). In the hyperthyroidism, blood reduced glutathione (GSH) levels were lower, erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities were higher than in the control group, but these changes were not significant. Post-treatment in each of the three groups the GSH levels were increased significantly as compared to the pretreatment levels (p < 0.001). There was significant decrease in the SOD activity post treatment (p < 0.01 in all three groups). Post-treatment CAT activity was decreased (p < 0.05 in the PTU group, p < 0.001 in the other two groups). The erythrocyte glutathione peroxidase (Gpx) activity was lower significantly in the hyperthyroidism as compared to the control group (p < 0.001). Post-treatment, in the three groups Gpx activity increased significantly as compared to the pretreatment levels (p < 0.05 in the PTU group, p < 0.001 in the PTU + PRP group and PTU + PRP + vitE group).
We considered that giving all three treatments would be useful to the prevention of oxidative stress in the hyperthyroidism states.
本研究旨在检测甲状腺功能亢进状态下及给予不同治疗后脂质过氧化和抗氧化状态。
我们检测了44例甲状腺功能亢进患者和19例甲状腺功能正常的健康对照者。根据治疗方法将患者分为三组：丙硫氧嘧啶（PTU）组、PTU+普萘洛尔（PRP）组、PTU+PRP+维生素E（vitE）组。
与对照组相比，甲状腺功能亢进患者血浆丙二醛（MDA）水平显著升高（p<0.001）。治疗后MDA水平显著降低（PTU+PRP组和PTU+PRP+vitE组p<0.001，PTU组p<0.01）。甲状腺功能亢进时，血液中还原型谷胱甘肽（GSH）水平较低，红细胞超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性高于对照组，但这些变化不显著。三组治疗后GSH水平均较治疗前显著升高（p<0.001）。治疗后SOD活性显著降低（三组均为p<0.01）。治疗后CAT活性降低（PTU组p<0.05，其他两组p<0.001）。与对照组相比，甲状腺功能亢进时红细胞谷胱甘肽过氧化物酶（Gpx）活性显著降低（p<0.001）。治疗后，三组Gpx活性均较治疗前显著升高（PTU组p<0.05，PTU+PRP组和PTU+PRP+vitE组p<0.001）。
我们认为给予这三种治疗方法均有助于预防甲状腺功能亢进状态下的氧化应激。
