Krishnamacharya Healing and Yoga Foundation, Chennai 600028, India.
Neurochem Res. 2013 Jan;38(1):42-9. doi: 10.1007/s11064-012-0885-z. Epub 2012 Sep 18.
This study aimed to elucidate the effect of 6-n-propylthiouracil (PTU)-induced hypothyroidism on oxidative stress parameters and expression of antioxidant enzymes in cerebral cortex of rat brain during postnatal development. A significant decrease in levels of lipid peroxidation and H(2)O(2) were seen in 7 and 30 days old PTU-treated rats with respect to their controls. Significantly decreased activities of superoxide dismutase (SOD) and catalase (CAT) along with the translated products of SOD1 and SOD2 were observed in 7, 15 and 30 days old PTU-treated rats as compared to their respective controls. However, increase in translated product of CAT was seen in all age groups of PTU-treated rats. Glutathione peroxidase activity was decreased in 7 days and increased in 15 days old PTU-treated rats with respect to their control groups. Histological sections clearly show a decline in neuronal migration with neurons packed together in the hypothyroid group as compared to the control.
本研究旨在阐明 6-正丙基硫氧嘧啶（PTU）诱发的甲状腺功能减退症对出生后发育过程中大鼠大脑皮质氧化应激参数和抗氧化酶表达的影响。与对照组相比，7 天和 30 天龄的 PTU 处理大鼠的脂质过氧化和 H2O2 水平显著降低。与相应对照组相比，7、15 和 30 天龄的 PTU 处理大鼠的超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性及其 SOD1 和 SOD2 的翻译产物显著降低。然而，所有年龄组的 PTU 处理大鼠的 CAT 翻译产物均增加。与对照组相比，7 天和 15 天龄的 PTU 处理大鼠的谷胱甘肽过氧化物酶活性降低。与对照组相比，甲状腺功能减退组的神经元迁移减少，神经元聚集在一起。组织学切片清楚地显示，与对照组相比，甲状腺功能减退组的神经元迁移减少，神经元聚集在一起。
