Seven A, Civelek S, Inci E, Inci F, Korkut N, Burçak G
Department of Biochemistry, Cerrahpaşa Medical Faculty, Istanbul University, Turkey.
Clin Biochem. 1999 Jul;32(5):369-73. doi: 10.1016/s0009-9120(99)00022-3.
In this study, plasma lipid peroxidation as assessed by thiobarbituric acid reactive substances and erythrocyte antioxidant status markers namely CuZn superoxide dismutase, glutathione peroxidase, glutathione and plasma levels of vitamin C and E were investigated in 20 patients with larygneal carcinoma and 15 healthy controls.
Lipid peroxidation was observed to be significantly higher (0.01 > p > 0.001) in the larynx carcinoma group in comparison to the healthy controls. Both stage I + 11 and stage III carcinoma patients were observed to have significantly higher thiobarbituric acid reactive substances than the control group. A significant difference was found in plasma vitamin E level between the control group and stage I + 11 and stage III carcinoma patients (p < 0.01, 0.05 > p > 0.02, respectively).
Our findings reveal the presence of increased lipooxidative damage in laryngeal carcinoma patients, but no change with respect to the endogenous antioxidant components-GSH, GSH Px, and CuZn SOD.
在本研究中，对20例喉癌患者和15名健康对照者进行了研究，通过硫代巴比妥酸反应性物质评估血浆脂质过氧化情况，并检测红细胞抗氧化状态标志物，即铜锌超氧化物歧化酶、谷胱甘肽过氧化物酶、谷胱甘肽以及血浆维生素C和E水平。
观察到喉癌组的脂质过氧化水平显著高于健康对照组（0.01 > p > 0.001）。I + II期和III期癌患者的硫代巴比妥酸反应性物质均显著高于对照组。对照组与I + II期和III期癌患者的血浆维生素E水平存在显著差异（分别为p < 0.01，0.05 > p > 0.02）。
我们的研究结果表明喉癌患者存在脂质氧化损伤增加的情况，但内源性抗氧化成分——谷胱甘肽（GSH）、谷胱甘肽过氧化物酶（GSH Px）和铜锌超氧化物歧化酶（CuZn SOD）没有变化。
