Sharma R P, Singh V, Janicak P G, Javaid J I, Pandey G N
Department of Psychiatry, University of Illinois at Chicago, USA.
Schizophr Res. 1999 Aug 23;39(1):85-9. doi: 10.1016/s0920-9964(99)00014-6.
We examined the serotonergic system in drug-free inpatients [schizophrenia (n=28) and schizoaffective (n=7)] by administering a challenge dose of oral dl-fenfluramine (fenfluramine) in a controlled angiocatheter study. Seventeen of these patients were also randomized to a placebo condition in addition to receiving fenfluramine. Response to fenfluramine as reflected by changes in serum prolactin and cortisol were examined by repeated measures ANOVA, as well as Area Under the Curves (AUCs). The prolactin response, but not the cortisol response, was significantly correlated with measures of negative symptoms.
我们在一项对照性静脉导管研究中，通过给予口服dl-芬氟拉明（芬氟拉明）激发剂量，对无药物治疗的住院患者[精神分裂症患者（n = 28）和分裂情感性障碍患者（n = 7）]的血清素能系统进行了检查。这些患者中有17人除接受芬氟拉明外，还被随机分配到安慰剂组。通过重复测量方差分析以及曲线下面积（AUC）来检查血清催乳素和皮质醇变化所反映的对芬氟拉明的反应。催乳素反应而非皮质醇反应与阴性症状的测量指标显著相关。
