Newbold C, Craig A, Kyes S, Rowe A, Fernandez-Reyes D, Fagan T
Molecular Parasitology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK.
Int J Parasitol. 1999 Jun;29(6):927-37. doi: 10.1016/s0020-7519(99)00049-1.
The particular virulence of Plasmodium falciparum compared with the other malaria species which naturally infect humans is thought to be due to the way in which the parasite modifies the surface of the infected red cell. Approximately 16 hours into the asexual cycle, parasite encoded proteins appear on the red cell surface which mediate adherence to a variety of host tissues. Binding of infected red cells to vascular endothelium, a process which occurs in all infections, is thought to be an important factor in the pathogenesis of severe disease where concentration of organisms in particular organs such as the brain occurs. Binding to uninfected red cells to form erythrocyte rosettes, a property of some isolates, is linked to disease severity. Here we summarise the data on the molecular basis of these interactions on both the host and parasite surfaces and review the evidence for the involvement of particular receptors in specific disease syndromes. Finally we discuss the relevance of these data to the development of new treatments for malaria.
与其他自然感染人类的疟原虫物种相比，恶性疟原虫的特殊毒力被认为是由于该寄生虫修饰被感染红细胞表面的方式。在无性周期约16小时后，寄生虫编码的蛋白质出现在红细胞表面，介导与多种宿主组织的黏附。感染的红细胞与血管内皮的结合，这一过程在所有感染中都会发生，被认为是严重疾病发病机制中的一个重要因素，在严重疾病中，病原体在特定器官（如大脑）中聚集。一些分离株具有感染的红细胞与未感染的红细胞结合形成红细胞花环的特性，这与疾病严重程度有关。在这里，我们总结了关于宿主和寄生虫表面这些相互作用的分子基础的数据，并综述了特定受体参与特定疾病综合征的证据。最后，我们讨论这些数据与疟疾新疗法开发的相关性。
