Olatunde Adesola C, Cornwall Douglas H, Roedel Marshall, Lamb Tracey J
Department of Pathology, University of Utah, Emma Eccles Jones Medical Research Building, 15 N Medical Drive E, Room 1420A, Salt Lake City, UT 84112, USA.
Vaccines (Basel). 2022 Sep 14;10(9):1525. doi: 10.3390/vaccines10091525.
Malaria comprises a spectrum of disease syndromes and the immune system is a major participant in malarial disease. This is particularly true in relation to the immune responses elicited against blood stages of -parasites that are responsible for the pathogenesis of infection. Mouse models of malaria are commonly used to dissect the immune mechanisms underlying disease. While no single mouse model of infection completely recapitulates all the features of malaria in humans, collectively the existing models are invaluable for defining the events that lead to the immunopathogenesis of malaria. Here we review the different mouse models of infection that are available, and highlight some of the main contributions these models have made with regards to identifying immune mechanisms of parasite control and the immunopathogenesis of malaria.
疟疾包含一系列疾病综合征，免疫系统是疟疾发病过程中的主要参与者。在针对导致感染发病机制的疟原虫血液阶段引发的免疫反应方面尤其如此。疟疾的小鼠模型常用于剖析疾病背后的免疫机制。虽然没有一种单一的感染小鼠模型能完全重现人类疟疾的所有特征，但总体而言，现有模型对于确定导致疟疾免疫发病机制的事件非常有价值。在这里，我们回顾了现有的不同感染小鼠模型，并强调了这些模型在识别寄生虫控制的免疫机制和疟疾免疫发病机制方面所做出的一些主要贡献。
