Wan J, Poo M
Department of Biology, University of California at San Diego, La Jolla, CA 92093, USA.
Science. 1999 Sep 10;285(5434):1725-8. doi: 10.1126/science.285.5434.1725.
Electrical activity plays a critical role in shaping the structure and function of synaptic connections in the nervous system. In Xenopus nerve-muscle cultures, a brief burst of action potentials in the presynaptic neuron induced a persistent potentiation of neuromuscular synapses that exhibit immature synaptic functions. Induction of potentiation required an elevation of postsynaptic Ca2+ and expression of potentiation appeared to involve an increased probability of transmitter secretion from the presynaptic nerve terminal. Thus, activity-dependent persistent synaptic enhancement may reflect properties characteristic of immature synaptic connections, and bursting activity in developing spinal neurons may promote functional maturation of the neuromuscular synapse.
电活动在塑造神经系统突触连接的结构和功能方面起着关键作用。在非洲爪蟾神经-肌肉培养物中，突触前神经元中短暂的动作电位爆发可诱导神经肌肉突触的持续增强，这些突触表现出不成熟的突触功能。增强的诱导需要突触后Ca2+升高，而增强的表达似乎涉及突触前神经末梢递质分泌概率的增加。因此，依赖活动的持续性突触增强可能反映了不成熟突触连接的特性，发育中的脊髓神经元的爆发活动可能促进神经肌肉突触的功能成熟。
