Bao J X, Kandel E R, Hawkins R D
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Science. 1997 Feb 14;275(5302):969-73. doi: 10.1126/science.275.5302.969.
Posttetanic potentiation (PTP) is a common form of short-term synaptic plasticity that is generally thought to be entirely presynaptic. Consistent with that idea, PTP of evoked excitatory postsynaptic potentials at Aplysia sensory-motor neuron synapses in cell culture was reduced by presynaptic injection of a slow calcium chelator and was accompanied by an increase in the frequency but not the amplitude of spontaneous excitatory postsynaptic potentials. However, PTP was also reduced by postsynaptic injection of a rapid calcium chelator or postsynaptic hyperpolarization. Thus, PTP at these synapses is likely to involve a postsynaptic induction mechanism in addition to the known presynaptic mechanisms.
强直后增强（PTP）是短期突触可塑性的一种常见形式，通常被认为完全是突触前的。与这一观点一致的是，在细胞培养中，通过突触前注射一种缓慢的钙螯合剂可降低海兔感觉运动神经元突触处诱发的兴奋性突触后电位的PTP，同时伴有自发性兴奋性突触后电位频率增加但幅度不变。然而，通过突触后注射快速钙螯合剂或突触后超极化也可降低PTP。因此，这些突触处的PTP除了已知的突触前机制外，可能还涉及突触后诱导机制。
