Konstas A G, Maltezos A C, Gandi S, Hudgins A C, Stewart W C
University Department of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece.
Am J Ophthalmol. 1999 Jul;128(1):15-20. doi: 10.1016/s0002-9394(99)00073-2.
To compare the 24-hour diurnal ocular hypotensive efficacy of two dosing regimens of latanoprost, once daily (8 AM or 10 PM), vs timolol maleate, twice daily.
We measured six diurnal intraocular pressure curves (6 AM, 10 AM, 2 PM, 6 PM, 10 PM, and 2 AM) in one randomly selected eye of 34 Greek patients newly diagnosed with primary open-angle glaucoma. The first diurnal curve was an untreated baseline. Patients began taking timolol 0.5%, twice daily, for 2 months. Patients were randomly assigned to latanoprost 0.005% given at 8 AM or 10 PM for 1 month and then changed to the other dosing regimen for 1 month. A diurnal curve was performed after each dosing period.
The baseline diurnal pressure for all 34 subjects was 23.1 +/- 3.7 mm Hg. The average intraocular pressures at 6 AM for patients who were given latanoprost in the evening (17.9 +/- 2.9 mm Hg) was statistically lower than that in patients given timolol solution (20.1 +/- 2.5 mm Hg, P = .003); however, patients who were given timolol demonstrated a similar diurnal intraocular pressure (19.1 +/- 2.8 mm Hg) to both morning (18.8 +/- 3.7 mm Hg) and evening doses (18.8 +/- 3.6 mm Hg) of latanoprost (P =.329). When the two latanoprost dosages were compared directly, evening administration provided a statistically lower intraocular pressure at 10 AM (P = .0001) and morning administration at 10 PM (P = .0001). This study had an 80% power to exclude a 1.2-mm Hg difference between groups.
This study indicates that in a small population, both latanoprost and timolol are effective in lowering intraocular pressure throughout a 24-hour period; however, latanoprost is most effective in the 12-hour to 24-hour period after administration.
比较拉坦前列素两种给药方案（每日一次，上午8点或晚上10点）与马来酸噻吗洛尔每日两次给药的24小时昼夜眼压降低效果。
我们测量了34例新诊断为原发性开角型青光眼的希腊患者一只随机选择眼睛的六条昼夜眼压曲线（上午6点、上午10点、下午2点、下午6点、晚上10点和凌晨2点）。第一条昼夜曲线为未治疗的基线。患者开始每日两次服用0.5%的噻吗洛尔，持续2个月。患者被随机分配至上午8点或晚上10点给予0.005%的拉坦前列素，持续1个月，然后换用另一种给药方案，持续1个月。每个给药期后进行一次昼夜曲线测量。
所有34名受试者的基线昼夜眼压为23.1±3.7 mmHg。晚上给予拉坦前列素的患者在上午6点的平均眼压（17.9±2.9 mmHg）在统计学上低于给予噻吗洛尔溶液的患者（20.1±2.5 mmHg，P = 0.003）；然而，给予噻吗洛尔的患者的昼夜眼压（19.1±2.8 mmHg）与拉坦前列素上午剂量（18.8±3.7 mmHg）和晚上剂量（18.8±3.6 mmHg）相似（P = 0.329）。直接比较两种拉坦前列素剂量时，晚上给药在上午10点的眼压在统计学上更低（P = 0.0001），上午给药在晚上10点的眼压在统计学上更低（P = 0.0001）。本研究有80%的把握度排除组间1.2 mmHg的差异。
本研究表明，在一小部分人群中，拉坦前列素和噻吗洛尔在24小时内均能有效降低眼压；然而，拉坦前列素在给药后12小时至24小时内最有效。
