Williams D L, Connelly M A, Temel R E, Swarnakar S, Phillips M C, de la Llera-Moya M, Rothblat G H
Department of Pharmacological Sciences, University Medical Centre, State University of New York at Stony Brook, 11794, USA.
Curr Opin Lipidol. 1999 Aug;10(4):329-39. doi: 10.1097/00041433-199908000-00007.
Scavenger receptor BI (SR-BI) mediates the selective uptake of HDL cholesteryl ester into steroidogenic cells and the liver and is a major determinant of the plasma HDL concentration in the mouse. Recent studies indicate that SR-BI also alters the metabolism of apolipoprotein B-containing particles and influences the development of atherosclerosis in several animal models. These results and the similar pattern of SR-BI expression in humans emphasize that it is important to learn how this receptor influences lipoprotein metabolism and atherosclerosis in people.
清道夫受体BI（SR-BI）介导高密度脂蛋白胆固醇酯选择性摄取进入类固醇生成细胞和肝脏，并且是小鼠血浆高密度脂蛋白浓度的主要决定因素。最近的研究表明，SR-BI还改变含载脂蛋白B颗粒的代谢，并在几种动物模型中影响动脉粥样硬化的发展。这些结果以及SR-BI在人类中的相似表达模式强调，了解该受体如何影响人类脂蛋白代谢和动脉粥样硬化非常重要。
