Zari Talal A, Al-Thebaiti Mesfer A
Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia,
Diabetes Metab Syndr Obes. 2018 Oct 12;11:619-631. doi: 10.2147/DMSO.S167293. eCollection 2018.
The aim of this study was to investigate the effects of stem extract on some physiological parameters in streptozotocin induced diabetes in male Wistar rats after 8 weeks.
The experimental rats were randomly assigned into four groups. Rats of group 1 were normal controls. Rats of group 2 were diabetic controls. Rats of group 3 were diabetic rats treated with stem extract. Rats of group 4 were non-diabetic rats, subjected to stem extract.
The lowest body weight gain was noticed in diabetic rats of group 2. Serum glucose, triglycerides, cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, ALP, total bilirubin, creatinine, blood urea nitrogen (BUN) and uric acid levels were significantly elevated in diabetic rats of group 2; however, total serum protein, albumin and high-density lipoprotein cholesterol were significantly reduced in diabetic rats of group 2.
Treatments with stem extract in diabetic rats revealed notable diminishing and protecting effects of physiological modifications. Therefore, this study revealed the significance of using stem extract as a promising remedial agent to treat diabetes and its complications.
本研究旨在调查8周后茎提取物对链脲佐菌素诱导的雄性Wistar大鼠糖尿病某些生理参数的影响。
将实验大鼠随机分为四组。第1组大鼠为正常对照组。第2组大鼠为糖尿病对照组。第3组大鼠为接受茎提取物治疗的糖尿病大鼠。第4组大鼠为接受茎提取物的非糖尿病大鼠。
第2组糖尿病大鼠的体重增加最少。第2组糖尿病大鼠的血清葡萄糖、甘油三酯、胆固醇、低密度脂蛋白胆固醇、极低密度脂蛋白胆固醇、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、碱性磷酸酶、总胆红素、肌酐、血尿素氮（BUN）和尿酸水平显著升高；然而，第2组糖尿病大鼠的血清总蛋白、白蛋白和高密度脂蛋白胆固醇显著降低。
糖尿病大鼠接受茎提取物治疗显示出对生理改变的显著减轻和保护作用。因此，本研究揭示了使用茎提取物作为治疗糖尿病及其并发症的有前景的治疗剂的重要性。
