淋病奈瑟菌por基因座的遗传多样性和镶嵌现象。
Genetic diversity and mosaicism at the por locus of Neisseria gonorrhoeae.
作者信息
Fudyk T C, Maclean I W, Simonsen J N, Njagi E N, Kimani J, Brunham R C, Plummer F A
机构信息
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.
出版信息
J Bacteriol. 1999 Sep;181(18):5591-9. doi: 10.1128/JB.181.18.5591-5599.1999.
Abstract
The por genes of the predominant serovars of Neisseria gonorrhoeae circulating in a high-frequency transmitter core group located in Nairobi, Kenya, were examined for nucleotide sequence polymorphism. The level of por gene diversity did not differ significantly between core group-derived gonococcal strains and gonococcal strains originating elsewhere. However, por mosaicism appeared to be more frequent among core group-derived strains, suggesting that recombination of different por sequences may be a important strategy by which N. gonorrhoeae generates por gene diversity within core group populations. Despite extensive sequence variability, por expressed by gonococcal isolates of different geographic origin exhibited conserved patterns of nucleotide change, suggesting that diversity among por alleles may also be finite.
摘要
对肯尼亚内罗毕一个高频传播核心群体中流行的淋病奈瑟菌主要血清型的por基因进行了核苷酸序列多态性检测。核心群体来源的淋球菌菌株与其他地方来源的淋球菌菌株之间，por基因的多样性水平没有显著差异。然而，por基因镶嵌现象在核心群体来源的菌株中似乎更为常见，这表明不同por序列的重组可能是淋病奈瑟菌在核心群体中产生por基因多样性的重要策略。尽管存在广泛的序列变异性，但不同地理来源的淋球菌分离株所表达的por基因呈现出保守的核苷酸变化模式，这表明por等位基因之间的多样性可能也是有限的。
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