恒河猴淋巴隐病毒中爱泼斯坦-巴尔病毒LMP2B同源物进化的强大选择压力。
Strong selective pressure for evolution of an Epstein-Barr virus LMP2B homologue in the rhesus lymphocryptovirus.
作者信息
Rivailler P, Quink C, Wang F
机构信息
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
J Virol. 1999 Oct;73(10):8867-72. doi: 10.1128/JVI.73.10.8867-8872.1999.
Abstract
Latent membrane protein 2B (LMP2B) is expressed during latent Epstein-Barr virus (EBV) infection, but little is known about its role. The goal of this study was to determine whether an LMP2B homologue is conserved in the rhesus monkey lymphocryptovirus (LCV). Both rhesus LCV LMP2A and LMP2B genes were cloned and sequenced. The rhesus LCV LMP2B gene is positionally conserved, and the EBNA-2 responsiveness and the bidirectional nature of the LMP1-LMP2B promoter have also been functionally conserved. However, this region of the genome encoding the LMP1, LMP1-LMP2B promoter, and LMP2B first exon demonstrates the most dramatic nucleotide sequence divergence between human and nonhuman LCV observed to date. Evolution of the rhesus LCV LMP2B promoter and transcript despite the dynamic nature of this genomic region reflects strong selective pressure for a yet-to-be-identified LMP2B function.
摘要
潜伏膜蛋白2B（LMP2B）在爱泼斯坦-巴尔病毒（EBV）潜伏感染期间表达，但其作用尚不清楚。本研究的目的是确定恒河猴淋巴细胞隐病毒（LCV）中是否存在保守的LMP2B同源物。克隆并测序了恒河猴LCV的LMP2A和LMP2B基因。恒河猴LCV的LMP2B基因在位置上是保守的，并且EBNA-2反应性以及LMP1-LMP2B启动子的双向性质在功能上也得到了保守。然而，编码LMP1、LMP1-LMP2B启动子和LMP2B第一外显子的基因组区域显示出迄今为止在人类和非人类LCV之间观察到的最显著的核苷酸序列差异。尽管该基因组区域具有动态性质，但恒河猴LCV LMP2B启动子和转录本的进化反映了对尚未确定的LMP2B功能的强大选择压力。
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