Su B, Zhu Q, Gao K, Yuan C, Jia Z
Department of Chemistry, Lanzhou University, People's Republic of China.
Planta Med. 1999 Aug;65(6):558-61. doi: 10.1055/s-1999-14026.
A new lignan glucoside, the first 7,9'-monoepoxyte-trahydrofuran type lignan with the cis-relationship of H-7 and H-8, named tibeticoside (1), as well as ten known compounds have been isolated from the medicinal plant (roots, stems and leaves) Lancea tibetica. The structure of tibeticoside (1) has been elucidated on the basis of chemical and spectral evidence, especially by 2D-NMR (1H-1H COSY, HMQC, HMBC, NOESY). In addition, sylvatesmin (6) exhibited effective antitumor activity on B16 cells.
从藏药川西獐牙菜（全草）中分离得到一个新的木脂素苷——首个具有H-7与H-8顺式关系的7,9'-单环氧四氢呋喃型木脂素，命名为川西獐牙菜苷（1），以及10个已知化合物。通过化学和波谱数据，特别是二维核磁共振谱（1H-1H COSY、HMQC、HMBC、NOESY）确定了川西獐牙菜苷（1）的结构。此外，水苏碱（6）对B16细胞显示出有效的抗肿瘤活性。
