日本金粟兰中的木脂素成分

Lignan constituents from Chloranthus japonicus Sieb.

作者信息

Kuang Hai-Xue, Xia Yong-Gang, Yang Bing-You, Wang Qiu-Hong, Lü Shao-Wa

机构信息

Heilongjiang University of Chinese Medicine, No. 24, Heping Road, Harbin, 150040, PR China.

出版信息

Arch Pharm Res. 2009 Mar;32(3):329-34. doi: 10.1007/s12272-009-1303-1. Epub 2009 Apr 23.

DOI:10.1007/s12272-009-1303-1

PMID:19387574

Abstract

A new coumarinolignan glucoside named yinxiancaoside C, along with five known benzofuran lignans, have been isolated from the whole plant of Chloranthus japonicus Sieb. The structures of compounds 1-6 were elucidated by chemical and spectroscopic methods including 1D-NMR, 2D-NMR, ESI-MS and HR-ESI-MS. Five known benzofuran lignans were firstly discovered in the Chloranthaceae. In addition, the cytotoxic activity of the isolated compounds against human hepatoma (Hepg-2), ovarian carcinoma (OV420), and breast cancer (MCF-7) cells was investigated by MTT method.

摘要

从日本金粟兰（Chloranthus japonicus Sieb.）全草中分离得到了一种名为银线草苷C的新香豆素木脂苷以及五种已知的苯并呋喃木脂素。通过一维核磁共振（1D-NMR）、二维核磁共振（2D-NMR）、电喷雾电离质谱（ESI-MS）和高分辨电喷雾电离质谱（HR-ESI-MS）等化学和光谱方法阐明了化合物1-6的结构。五种已知的苯并呋喃木脂素首次在金粟兰科植物中被发现。此外，采用MTT法研究了分离得到的化合物对人肝癌细胞（Hepg-2）、卵巢癌细胞（OV420）和乳腺癌细胞（MCF-7）的细胞毒性活性。