Langberg H, Skovgaard D, Bülow J, Kjaer M
Sports Medicine Research Unit, Department of Rheumatology H, Bispebjerg Hospital, DK-2400 Copenhagen, Denmark.
J Appl Physiol (1985). 1999 Sep;87(3):999-1002. doi: 10.1152/jappl.1999.87.3.999.
In the present study, tissue pressure in the peritendinous area ventral to the human Achilles tendon was determined. The pressure was measured during rest and intermittent isometric calf muscle exercise at three torques (56, 112, and 168 Nm) 20, 40 and 50 mm proximal to the insertion of the tendon in 11 healthy, young individuals. In all experiments a linear significant decrease in pressure was obtained with increasing torque [e.g., at 40 mm: -0.4 +/- 0.3 mmHg (rest) to -135 +/- 12 mmHg (168 Nm)]. No significant differences were obtained among the three areas measured. On the basis of these observations, microdialysis was performed in the peritendinous region with a colloid osmotic active substance (Dextran 70, 0.1 g/ml) added to the perfusate with the aim of counteracting the negative tissue pressure. Dialysate volume was found to be fully restored (100 +/- 4%) during exercise. It is concluded that a marked negative tissue pressure is generated in the peritendinous space around the Achilles tendon during exercise in humans. Negative tissue pressure could lead to fluid shift and could be involved in the increase in blood flow previously noted in the peritendinous tissue during exercise (H. Langberg, J. Bülow, and M. Kjaer. Acta Physiol. Scand. 163: 149-153, 1998; H. Langberg, J. Bülow, and M. Kjaer. Clin. Physiol. 19: 89-93, 1999).
在本研究中，测定了人跟腱腹侧腱周区域的组织压力。在11名健康年轻个体中，于跟腱止点近端20、40和50毫米处，在静息状态以及三个扭矩（56、112和168牛米）的间歇性等长小腿肌肉运动过程中测量压力。在所有实验中，随着扭矩增加压力呈线性显著下降[例如，在40毫米处：从-0.4±0.3毫米汞柱（静息）降至-135±12毫米汞柱（168牛米）]。所测量的三个区域之间未获得显著差异。基于这些观察结果，在腱周区域进行了微透析，向灌注液中添加了具有胶体渗透活性的物质（右旋糖酐70，0.1克/毫升），目的是抵消负组织压力。发现运动期间透析液体积完全恢复（100±4%）。得出结论，在人类运动期间，跟腱周围的腱周间隙会产生显著的负组织压力。负组织压力可能导致液体转移，并可能与先前在运动期间腱周组织中观察到的血流增加有关（H. 朗伯格、J. 比洛和M. 克亚尔。《生理学杂志》163: 149 - 153, 1998；H. 朗伯格、J. 比洛和M. 克亚尔。《临床生理学》19: 89 - 93, 1999）。
