Shannon A D, Quin J W, Jones M A
Q J Exp Physiol Cogn Med Sci. 1976 Jul;61(3):169-84. doi: 10.1113/expphysiol.1976.sp002351.
An acute pain stimulus resulted in elevated lymph flow and output of cells from the popliteal lymph node of the sheep in the first 15 min after the stress. Efferent lymph flow increased by an average of 93% above the mean resting flow and cell output rose by an average of 170% during this period, but by 30 min after the stress, values for both lymph flow and cell output had returned to normal. The cell content of the efferent lymph was significantly higher in the first 15 min after the acute stress and it is suggested that there is a sizeable pool of lymphocytes within the resting popliteal node which can be mobilized into the lymph by an acute stress. A single intravenous injection of 1 mg adrenaline the efferent lymph flow in all the sheep examined but gave rise to an increased cell output in only 50% of the sheep. This indicated that there may be other factors, possibly hormonal, involved in the movement of the pool of lymphocytes out of the regional lymph node following acute stress. Both acute pain stress and adrenaline resulted in an increased afferent popliteal lymph flow and output of cells from the regional tissues in the first 15 min after administration. The results are suggestive of a small pool of lymphocytes in the regional tissues which may be readily mobilized by either acute stress or adrenaline. Part of the increases in efferent and afferent lymph flow observed following acute stress and adrenaline appeared to be due to an increased lymph formation, presumably as a result of an increased capillary pressure. Nevertheless, it is considered that the greater part of the increased flow of lymph from both regions resulted from an accelerated movement of performed lymph.
急性疼痛刺激导致绵羊在应激后的前15分钟内腘淋巴结的淋巴流动增加以及细胞输出量增加。在此期间，传出淋巴流量平均比静息流量均值高出93%，细胞输出量平均增加170%，但在应激后30分钟，淋巴流量和细胞输出量的值均恢复正常。急性应激后最初15分钟内传出淋巴中的细胞含量显著更高，这表明在静息的腘淋巴结内存在大量淋巴细胞池，可通过急性应激动员进入淋巴。对所有受试绵羊单次静脉注射1毫克肾上腺素可增加传出淋巴流量，但仅50%的绵羊细胞输出量增加。这表明在急性应激后淋巴细胞池从区域淋巴结中移出的过程中可能涉及其他因素，可能是激素因素。急性疼痛应激和肾上腺素均导致给药后最初15分钟内腘淋巴结传入淋巴流量增加以及区域组织的细胞输出量增加。结果提示区域组织中存在一小部分淋巴细胞池，可通过急性应激或肾上腺素轻易动员。急性应激和肾上腺素后观察到的传出和传入淋巴流量增加部分似乎是由于淋巴生成增加，推测是由于毛细血管压力增加所致。然而，人们认为来自这两个区域的淋巴流量增加的更大部分是由于已生成淋巴的加速流动。
