乙琥胺在一名孕妇及其新生儿体内的药代动力学。

Ethosuximide pharmacokinetics in a pregnant patient and her newborn.

作者信息

Koup J R, Rose J Q, Cohen M E

出版信息

Epilepsia. 1978 Dec;19(6):535-9. doi: 10.1111/j.1528-1157.1978.tb05033.x.

DOI:10.1111/j.1528-1157.1978.tb05033.x

Abstract

Ethosuximide concentration in serum was monitored during the last trimester of pregnancy in a patient. After delivery, the decline in serum concentration of ethosuximide was observed in the nonnursing neonate. The half-life of elimination of transplacentally acquired ethosuximide in this neonate was 41.3 hr. The ratio of breast milk to maternal serum concentration of ethosuximide was approximately 1. A total daily exposure to ethosuximide of 12.8 to 38.4 mg (3.6 to 11.0 mg/kg) as a result of nursing was predicted.

摘要

对一名患者在妊娠晚期监测了血清中乙琥胺的浓度。分娩后，在未进行母乳喂养的新生儿中观察到乙琥胺血清浓度下降。该新生儿经胎盘获得的乙琥胺的消除半衰期为41.3小时。母乳与母体血清中乙琥胺浓度的比值约为1。预计由于母乳喂养，新生儿每日乙琥胺的总暴露量为12.8至38.4毫克（3.6至11.0毫克/千克）。