母亲及其哺乳婴儿的母乳和血浆中的乙琥胺。
Ethosuximide in human milk and in plasma of a mother and her nursed infant.
作者信息
Rane A, Tunell R
出版信息
Br J Clin Pharmacol. 1981 Dec;12(6):855-8. doi: 10.1111/j.1365-2125.1981.tb01320.x.
Abstract
1 The concentrations of ethosuximide were measured in the milk and in the plasma of a nursing mother and her infant during a period of 4.5 months after delivery. 2 The maternal and the infant's plasma concentrations rose after delivery. 3 The milk concentration ethosuximide was similar to that in maternal plasma on the third day after delivery. During the following 2 months the average milk/maternal plasma concentration ratio was 0.80. The rise in ethosuximide concentration in milk during the first month was steeper than that in infant's plasma, which may be due to an increase in the infant's clearance of the drug. 4 Even if the infant has subtherapeutic plasma concentrations it is recommended to control the levels in infants that are nursed by ethosuximide-treated mothers when nursing has been established.
摘要
1 在分娩后的4.5个月内，对一位哺乳期母亲及其婴儿的乳汁和血浆中的乙琥胺浓度进行了测量。2 分娩后母亲和婴儿的血浆浓度升高。3 产后第三天，乳汁中乙琥胺的浓度与母亲血浆中的浓度相似。在接下来的2个月中，乳汁/母亲血浆浓度的平均比值为0.80。第一个月乳汁中乙琥胺浓度的上升比婴儿血浆中的上升更为陡峭，这可能是由于婴儿对药物的清除率增加所致。4 即使婴儿的血浆浓度低于治疗水平，仍建议在建立哺乳后，对由服用乙琥胺的母亲哺乳的婴儿的药物水平进行监测。
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本文引用的文献
1
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2
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J Clin Pharmacol J New Drugs. 1969 Nov-Dec;9(6):393-8.
3
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4
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5
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Lancet. 1972 Jun 3;1(7762):1235-6. doi: 10.1016/s0140-6736(72)90954-3.
6
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7
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