妊娠和哺乳期癫痫女性使用乙琥胺。胎盘转运、哺乳婴儿的血清浓度及临床状况。
Ethosuximide in epileptic women during pregnancy and lactation period. Placental transfer, serum concentrations in nursed infants and clinical status.
作者信息
Kuhnz W, Koch S, Jakob S, Hartmann A, Helge H, Nau H
出版信息
Br J Clin Pharmacol. 1984 Nov;18(5):671-7. doi: 10.1111/j.1365-2125.1984.tb02528.x.
Abstract
A total of 10 epileptic mothers treated with ethosuximide (ES) as well as their 13 newborns were included in this study. At birth foetal/maternal serum concentration ratios were 0.97 +/- 0.02 (n = 7) and ES half-lives in three neonates were 32, 37 and 38 h. The breast milk concentrations of ES were similar to those in maternal serum (milk/serum: 0.86 +/- 0.08, n = 12) and the nursed infants maintained serum levels between 15 and 40 micrograms/ml. Two major malformations (bilateral clefting, hare-lip) were observed in two neonates whose mothers received either ES/PB or ES/PMD comedication. The number of minor anomalies was higher in the ES group (6.2, n = 12) than in the pair-matched control group of infants born to non-epileptic mothers (2.1, n = 10). Neonatal behaviour complications occurred in seven infants, two of them were severely affected.
摘要
本研究纳入了10名接受乙琥胺（ES）治疗的癫痫母亲及其13名新生儿。出生时胎儿/母体血清浓度比为0.97±0.02（n = 7），3名新生儿的ES半衰期分别为32、37和38小时。ES在母乳中的浓度与母体血清中的浓度相似（母乳/血清：0.86±0.08，n = 12），接受母乳喂养的婴儿血清水平维持在15至40微克/毫升之间。在两名母亲接受ES/PB或ES/PMD联合用药的新生儿中观察到两种主要畸形（双侧唇腭裂、唇裂）。ES组（6.2，n = 12）的轻微异常数量高于非癫痫母亲所生婴儿的配对对照组（2.1，n = 10）。7名婴儿出现新生儿行为并发症，其中2名受严重影响。
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