de Bournonville C, Maugendre S, Belleguic C, Corbineau T, Lena H, Desrues B, Delaval P
Service de Pneumologie, CHU de Rennes.
Rev Pneumol Clin. 1999 Jun;55(3):177-80.
Mature teratoma is the most frequent primary germ-cell tumor occurring in the mediastinum. These tumors present characteristic mature cells derived from all three types of embryogenesis tissues. We report two cases. The typical presentation is a cyst-like noninvasive, heterogeneous and calcified formation in the anterior mediastinum, usually in young subjects. Tumor markers, alpha-fetoprotein and beta-gonadotropin, are contributive as they rule out mature tumors if positive. Surgery is the treatment of choice, although adherence to neighboring structures usually makes complete excision difficult. Pathology provides the precise diagnosis, ruling out an immature component.
成熟畸胎瘤是纵隔最常见的原发性生殖细胞肿瘤。这些肿瘤呈现出源自所有三种胚胎发生组织类型的特征性成熟细胞。我们报告两例病例。典型表现为前纵隔内类似囊肿的非侵袭性、异质性和钙化性肿物，通常见于年轻患者。肿瘤标志物甲胎蛋白和β-促性腺激素有助于诊断，因为如果它们呈阳性则可排除成熟肿瘤。手术是首选治疗方法，尽管肿瘤与邻近结构粘连通常使完整切除困难。病理学可提供精确诊断，排除不成熟成分。
