Iyoda A, Hiroshima K, Yusa T, Toyozaki T, Fujisawa T, Ohwada H
Division of Pathology, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, Japan.
Anticancer Res. 2000 Sep-Oct;20(5C):3723-6.
We encountered a case of mediastinal immature teratoma which revealed the feature of the so-called growing teratoma syndrome. A 20-year-old male with a cough was discovered to have an abnormal shadow in the mediastinum. The serum AFP was elevated to 3600 ng/ml. The specimen with percutaneous needle biopsy revealed mature teratoma. The tumor was suspected to be mature teratoma with a malignant component because of the high level of serum AFP and he underwent chemotherapy. The serum AFP declined markedly but the tumor further enlarged. The resected tumor was diagnosed as immature teratoma, although most of the tumor tissue was mature component.
我们遇到一例纵隔未成熟畸胎瘤，其表现出所谓的生长畸胎瘤综合征的特征。一名20岁咳嗽男性被发现纵隔有异常阴影。血清甲胎蛋白（AFP）升高至3600 ng/ml。经皮针吸活检标本显示为成熟畸胎瘤。由于血清AFP水平高，该肿瘤被怀疑为含有恶性成分的成熟畸胎瘤，患者接受了化疗。血清AFP明显下降，但肿瘤进一步增大。切除的肿瘤被诊断为未成熟畸胎瘤，尽管大部分肿瘤组织为成熟成分。
