Yabuki A, Suzuki S, Matsumoto M, Nishinakagawa H
Department of Veterinary Anatomy, Faculty of Agriculture, Kagoshima University, Japan.
J Vet Med Sci. 1999 Aug;61(8):891-6. doi: 10.1292/jvms.61.891.
In the present study, we investigated the sexual dimorphisms, effects of castration and sex hormone treatment, and strain differences in the morphology of mouse kidney by measuring the percentage of renal corpuscles with cuboidal cells in the parietal layer of the glomerular capsule, the diameter of renal corpuscles and the number of nuclei of epithelial cells in the proximal convoluted tubule. In ICR mice, the percentage of renal corpuscles with cuboidal cells and the diameter of renal corpuscles were larger in males than in females, and the numbers of nuclei were lower in males than in females. All of these parameters became similar to those of intact females by orchiectomy, and restored to levels similar to those in intact males after testosterone treatment to orchiectomized males. On the other hand, ovariectomy and estradiol treatment gave no effects to any of these parameters. Similar sexual dimorphisms were observed in BALB/c, C57BL/6, C3H/He and DBA/2 mice as in ICR mice, although the diameter of renal corpuscles was not significantly different between males and females in BALB/c mice. Strain differences were observed in each of these three parameters among the 5 strains. In conclusion, the present study demonstrated sexual dimorphisms, effects of castration and sex hormone treatment, and strain differences in the morphology of mouse kidney by morphometrical analysis.
在本研究中，我们通过测量肾小球囊壁层中具有立方体细胞的肾小体百分比、肾小体直径以及近端曲管中上皮细胞核的数量，研究了小鼠肾脏形态的性别差异、去势和性激素处理的影响以及品系差异。在ICR小鼠中，具有立方体细胞的肾小体百分比和肾小体直径雄性大于雌性，而细胞核数量雄性低于雌性。通过睾丸切除，所有这些参数变得与完整雌性相似，对去势雄性小鼠进行睾酮处理后恢复到与完整雄性相似的水平。另一方面，卵巢切除和雌二醇处理对这些参数均无影响。与ICR小鼠类似，在BALB/c、C57BL/6、C3H/He和DBA/2小鼠中也观察到了相似的性别差异，尽管BALB/c小鼠中雄性和雌性的肾小体直径没有显著差异。在这5个品系的这三个参数中均观察到了品系差异。总之，本研究通过形态计量分析证明了小鼠肾脏形态的性别差异、去势和性激素处理的影响以及品系差异。
