Dong V M, Womer K L, Sayegh M H
Laboratory of Immunogenetics and Transplantation, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Pediatr Transplant. 1999 Aug;3(3):181-92. doi: 10.1034/j.1399-3046.1999.00042.x.
Recent advances have enabled researchers to induce tolerance in animal transplant models. Although it has been relatively easy to do so in rodents, it has been much more difficult to translate such strategies into primates. Understanding the cellular and molecular mechanisms of the alloimmune response has prompted the development of novel strategies that may obviate the need for immunosuppression in humans. Mechanisms of tolerance and promising new therapies, as well as the inherent difficulties in bringing them into clinical practice, are reviewed.
最近的进展使研究人员能够在动物移植模型中诱导耐受性。虽然在啮齿动物中做到这一点相对容易，但将此类策略转化应用于灵长类动物则困难得多。对同种免疫反应的细胞和分子机制的了解促使了新策略的开发，这些策略可能无需对人类进行免疫抑制。本文综述了耐受性机制、有前景的新疗法以及将它们应用于临床实践中所固有的困难。
