Boas S R, Danduran M J, McColley S A
Department of Pediatrics, Children's Memorial Hospital, Chiacago, IL 60614, USA.
Med Sci Sports Exerc. 1999 Sep;31(9):1242-9. doi: 10.1097/00005768-199909000-00003.
The nature of a child's daily physical activity requires both aerobic and anaerobic energy metabolism. Aerobic exercise becomes compromised with advancing airway obstruction in children with cystic fibrosis (CF) and asthma (AS). Whether children with CF will have altered metabolic responses to supramaximal exercise when compared with asthmatics or healthy controls is still undetermined.
Twenty-five children with CF, 22 with AS, and 23 healthy controls (CN) performed an incremental graded aerobic and Wingate anaerobic test (WAnT) on a cycle ergometer. Analysis of gas exchange and ventilatory data was collected and averaged every 5 s to estimate ventilatory kinetics and energy system contributions during both tests.
The CF and AS groups had mild lower airway obstruction (FEF25-75% < 80%) as compared with the CN. All three groups demonstrated similar anaerobic (mean and peak power during the WAnT) and aerobic exercise performance (peak oxygen consumption). In contrast to the AS or CN groups, children with CF used a lower percentage of their peak VO2 and V(E) during each phase of the WAnT, suggesting a preferential use of ATP/phosphocreatine and glycolytic energy stores compared with aerobic pathways. Greater reliance on anaerobic pathways during the WAnT in children with CF could be due to the physiologic sequelae underlying chronic obstructive lung disease.
Oxygen uptake kinetics appeared similar for all three groups. Although the energy needed to perform the WAnT can be met by subjects with CF, abnormalities in energy metabolism may exist for this group during exercise.
儿童日常身体活动的性质需要有氧和无氧能量代谢。在患有囊性纤维化（CF）和哮喘（AS）的儿童中，有氧运动能力会随着气道阻塞的加重而受损。与哮喘患儿或健康对照组相比，CF患儿对超最大运动的代谢反应是否会发生改变仍未确定。
25名CF患儿、22名AS患儿和23名健康对照者（CN）在自行车测力计上进行递增式分级有氧运动和温盖特无氧试验（WAnT）。收集气体交换和通气数据，并每5秒进行一次平均，以估计两项测试期间的通气动力学和能量系统贡献。
与CN组相比，CF组和AS组存在轻度下气道阻塞（FEF25-75%<80%）。所有三组在无氧运动（WAnT期间的平均功率和峰值功率）和有氧运动表现（峰值耗氧量）方面表现相似。与AS组或CN组不同，CF患儿在WAnT的每个阶段使用的峰值VO2和V（E）百分比更低，这表明与有氧途径相比，他们更倾向于使用ATP/磷酸肌酸和糖酵解能量储备。CF患儿在WAnT期间对无氧途径的更大依赖可能是由于慢性阻塞性肺疾病的生理后遗症。
三组的摄氧动力学似乎相似。虽然CF患儿能够满足进行WAnT所需的能量，但该组在运动期间可能存在能量代谢异常。
