Kanaley J A, Weatherup-Dentes M M, Jaynes E B, Hartman M L
Department of Exercise Science, Syracuse University, New York 13244, USA.
J Clin Endocrinol Metab. 1999 Sep;84(9):3156-61. doi: 10.1210/jcem.84.9.5997.
Resting serum GH concentrations are decreased in obesity. In nonobese (NonOb) individuals, acute exercise of sufficient intensity increases GH levels; however, conflicting data exist concerning the GH response to exercise in obese individuals. To examine the exercise-induced GH response in obese individuals, we studied 8 NonOb, 11 lower body obese (LBO), and 12 upper body obese (UBO) women before, during, and after 30 min (0800-0830 h) of treadmill exercise at 70% oxygen consumption peak. Blood samples were taken every 5 min (0700-1300 h) and were analyzed for GH concentrations with a sensitive (0.002 microg/L) chemiluminescence assay. The impact of 16 weeks of aerobic exercise training on the GH response to exercise was also examined in the obese women. In response to exercise, the 6-h integrated GH concentration was significantly greater (P < 0.05) in the NonOb women (1006 +/- 220 min/microg x L) than in either of the obese groups (LBO, 435 +/- 136; UBO, 189 +/- 26 min/microg x L). No differences were found between the LBO and UBO women. The increased integrated GH concentrations could be accounted for by a greater 6-h GH production rate [micrograms per L distribution volume (Lv)] in the NonOb women than in either of the obese groups (NonOb, 45.6 +/- 12.3; LBO, 16.9 +/- 1.2; UBO, 8.7 +/- 0.64 microg/Lv; P < 0.05). This increase was attributed to a greater mass of GH secreted per pulse in the NonOb women (NonOb, 10.8 +/- 2.5; LBO, 4.9 +/- 0.8; UBO, 4.0 +/- 0.5 microg/Lv; P < 0.05, NonOb vs. both obese groups). After 16 weeks of aerobic training, maximal oxygen consumption increased from 44.7 +/- 2.2 to 48.5 +/- 1.9 mL/kg fat-free mass x min; P < 0.05), but no significant change in body composition occurred in the 10 obese women who completed the training. No change was observed in the GH response to exercise after training (n = 10; pre, 379 +/- 144; post, 350 +/- 55 min/microg x L). In conclusion, the GH response to exercise was attenuated in the obese women compared to NonOb women. Short term aerobic training improved fitness, but did not increase the GH response to exercise.
肥胖人群静息血清生长激素（GH）浓度降低。在非肥胖（NonOb）个体中，足够强度的急性运动可提高GH水平；然而，关于肥胖个体运动后GH反应的数据存在矛盾。为研究肥胖个体运动诱导的GH反应，我们对8名非肥胖、11名下半身肥胖（LBO）和12名上半身肥胖（UBO）女性在进行30分钟（08:00 - 08:30）跑步机运动（运动强度为耗氧量峰值的70%）之前、期间和之后进行了研究。每5分钟（07:00 - 13:00）采集血样，并用灵敏的（0.002微克/升）化学发光分析法分析GH浓度。我们还研究了16周有氧运动训练对肥胖女性运动后GH反应的影响。运动后，非肥胖女性6小时综合GH浓度（1006±220分钟/微克×升）显著高于肥胖组中的任何一组（LBO组为435±136；UBO组为189±26分钟/微克×升；P<0.05）。LBO组和UBO组女性之间未发现差异。非肥胖女性6小时GH产生率[微克/升分布容积（Lv）]高于肥胖组中的任何一组，这可以解释综合GH浓度的升高（非肥胖组为45.6±12.3；LBO组为16.9±1.2；UBO组为8.7±0.64微克/Lv；P<0.05）。这种升高归因于非肥胖女性每脉冲分泌的GH量更大（非肥胖组为10.8±2.5；LBO组为4.9±0.8；UBO组为4.0±0.5微克/Lv；P<0.05，非肥胖组与两个肥胖组相比）。经过16周的有氧训练，10名完成训练的肥胖女性的最大耗氧量从44.7±2.2增加到48.5±1.9毫升/千克去脂体重×分钟（P<
