Wideman L, Weltman J Y, Shah N, Story S, Veldhuis J D, Weltman A
Department of Medicine, University of Virginia, Charlottesville, Virginia 22903, USA.
J Appl Physiol (1985). 1999 Sep;87(3):1154-62. doi: 10.1152/jappl.1999.87.3.1154.
We examined gender differences in growth hormone (GH) secretion during rest and exercise. Eighteen subjects (9 women and 9 men) were tested on two occasions each [resting condition (R) and exercise condition (Ex)]. Blood was sampled at 10-min intervals from 0600 to 1200 and was assayed for GH by chemiluminescence. At R, women had a 3.69-fold greater mean calculated mass of GH secreted per burst compared with men (5.4 +/- 1.0 vs. 1.7 +/- 0.4 microg/l, respectively) and higher basal (interpulse) GH secretion rates, which resulted in greater GH production rates and serum GH area under the curve (AUC; 1,107 +/- 194 vs. 595 +/- 146 microg x l(-1) x min, women vs. men; P = 0.04). Compared with R, Ex resulted in greater mean mass of GH secreted per burst, greater mean GH secretory burst amplitude, and greater GH AUC (1,196 +/- 211 vs. 506 +/- 90 microg x l(-1) x min, Ex vs. R, respectively; P < 0.001). During Ex, women attained maximal serum GH concentrations significantly earlier than men (24 vs. 32 min after initiation of Ex, respectively; P = 0.004). Despite this temporal disparity, both genders had similar maximal serum GH concentrations. The change in AUC (adjusted for unequal baselines) was similar for men and women (593 +/- 201 vs. 811 +/- 268 microg x l(-1) x min), but there were significant gender-by-condition interactive effects on GH secretory burst mass, pulsatile GH production rate, and maximal serum GH concentration. We conclude that, although women exhibit greater absolute GH secretion rates than men both at rest and during exercise, exercise evokes a similar incremental GH response in men and women. Thus the magnitude of the incremental secretory GH response is not gender dependent.
我们研究了静息和运动期间生长激素（GH）分泌的性别差异。18名受试者（9名女性和9名男性）在两种情况下各接受了两次测试[静息状态（R）和运动状态（Ex）]。从06:00至12:00每隔10分钟采集一次血液，通过化学发光法检测GH。在静息状态下，女性每次脉冲分泌的GH平均计算质量比男性高3.69倍（分别为5.4±1.0与1.7±0.4微克/升），基础（脉冲间期）GH分泌率更高，这导致更高的GH产生率和血清GH曲线下面积（AUC；女性为1,107±194，男性为595±146微克×升⁻¹×分钟；P = 0.04）。与静息状态相比，运动导致每次脉冲分泌的GH平均质量更高、平均GH分泌脉冲幅度更大以及GH AUC更大（运动状态与静息状态分别为1,196±211与506±90微克×升⁻¹×分钟；P < 0.001）。在运动期间，女性达到最大血清GH浓度的时间明显早于男性（分别在运动开始后24分钟与32分钟；P = 0.004）。尽管存在这种时间差异，但两性的最大血清GH浓度相似。AUC的变化（针对不等基线进行调整）在男性和女性中相似（593±201与811±268微克×升⁻¹×分钟），但在GH分泌脉冲质量、脉冲性GH产生率和最大血清GH浓度方面存在显著的性别×状态交互作用。我们得出结论，尽管女性在静息和运动时的绝对GH分泌率均高于男性，但运动在男性和女性中引起的GH增量反应相似。因此，分泌性GH增量反应的幅度不依赖于性别。
