Romeis J C, Waterman B, Scherrer J F, Goldberg J, Eisen S A, Heath A C, Bucholz K K, Slutske W S, Lyons M J, Tsuang M T, True W R
School of Public Health, St. Louis University, Missouri 63108, USA.
J Stud Alcohol. 1999 Sep;60(5):653-62. doi: 10.15288/jsa.1999.60.653.
To obtain estimates of the relationship between alcoholism and health-related quality of life (HRQL) in twin pairs discordant for alcohol dependence.
In 1995, 1,258 male-male twin pair members of the Vietnam Era Twin Registry (total Registry N = 7.375 pairs) were administered a modified Medical Outcomes Study 36 Item Short Form (SF-36) and the Diagnostic Interview Schedule (DIS) to obtain measures of HRQL and a DSM-III-R criteria lifetime diagnosis of alcohol dependence. Mean within pair differences on eight separate SF-36 subscales were calculated for 436 remitted (no alcohol symptoms in the past 5 years) alcohol-dependent discordant twin pairs and for 194 recent (at least one alcohol symptom in the past 5 years) alcohol-dependent discordant pairs before and after adjustment for covariates. Covariates included lifetime physical illness, lifetime psychiatric disorders, lifetime drug dependence, lifetime nicotine dependence, current marital status, current income and severity.
In the unadjusted analysis remitted alcoholic twins compared to their nonalcoholic co-twins reported significantly lower mean scores for six of eight SF-36 subscales. Recent alcoholic twins, compared to their nonalcoholic co-twins, reported significantly lower mean scores for all of the SF-36 subscales. However, after simultaneous adjustment for all covariates, no SF-36 subscale mean, except "vitality" among recent alcoholic twins, was significantly different between alcoholic twins and their nonalcoholic co-twins.
Differences in HRQL between alcoholic and nonalcoholic co-twins is due to covariation from physical and psychiatric problems, drug and nicotine dependence, marital status, income and severity.
评估酒精依赖不一致的双胞胎对中酒精中毒与健康相关生活质量（HRQL）之间的关系。
1995年，越南时代双胞胎登记处的1258对男性双胞胎成员（登记处总数N = 7375对）接受了改良的医学结局研究36项简表（SF - 36）和诊断性访谈表（DIS），以获取HRQL测量值以及酒精依赖的DSM - III - R标准终生诊断。计算了436对已缓解（过去5年无酒精症状）的酒精依赖不一致双胞胎对和194对近期（过去5年至少有一个酒精症状）的酒精依赖不一致双胞胎对在八个单独的SF - 36子量表上的平均配对内差异，在对协变量进行调整之前和之后。协变量包括终生身体疾病、终生精神疾病、终生药物依赖、终生尼古丁依赖、当前婚姻状况、当前收入和严重程度。
在未经调整的分析中，与非酒精性双胞胎相比，已缓解的酒精性双胞胎在八个SF - 36子量表中的六个上报告的平均得分显著较低。与非酒精性双胞胎相比，近期酒精性双胞胎在所有SF - 36子量表上报告的平均得分显著较低。然而，在对所有协变量进行同时调整后，除了近期酒精性双胞胎中的“活力”子量表外，酒精性双胞胎与其非酒精性双胞胎在任何SF - 36子量表平均得分上均无显著差异。
酒精性和非酒精性双胞胎之间HRQL的差异是由于身体和精神问题、药物和尼古丁依赖以及婚姻状况、收入和严重程度的共同变化所致。
