Junquera L, Alonso D, Sampedro A, Fresno F, Albertos J M, López-Arranz J S
Department of Oral and Maxillofacial Surgery, University of Oviedo, Hospital Central de Asturias, Oviedo, Spain.
Head Neck. 1999 Oct;21(7):652-6. doi: 10.1002/(sici)1097-0347(199910)21:7<652::aid-hed10>3.0.co;2-e.
Primary surgery is the appropriate treatment for most pleomorphic adenomas of the salivary glands. However, no reliable criteria have been established to predict tumors with aggressive features.
In 44 patients treated for salivary pleomorphic adenoma, clinicopathologic features and flow cytometric findings were recorded. S-phase fractions were classified as low (0%-1%), intermediate (1.1%-5%), and high (>5%). The relationship between clinicopathologic parameters and flow cytometric DNA analysis was assessed with the Pearson's correlation coefficient.
The mean tumor size was 24.4 mm. Microscopically, myxoid structures predominated in 61.4% of cases. Only five specimens showed high S-phase fractions. All samples were DNA diploid (mean coefficient of variation 3.2%). S-phase fraction and tumor size correlated significantly (r = 0.73, P = 0.003). Two patients with recurrent tumors had high S-phase fractions both on the first resected specimens and at the time of the second operation.
The S-phase fraction may be a valuable predictor of aggressive behavior in salivary pleomorphic adenomas. High S-phase fractions were associated with higher tumor size and a greater tendency to recur.
对于大多数涎腺多形性腺瘤而言，原发性手术是合适的治疗方法。然而，尚未建立可靠的标准来预测具有侵袭性特征的肿瘤。
记录了44例接受涎腺多形性腺瘤治疗患者的临床病理特征和流式细胞术检测结果。S期细胞分数被分为低（0%-1%）、中（1.1%-5%）和高（>5%）。采用Pearson相关系数评估临床病理参数与流式细胞术DNA分析之间的关系。
肿瘤平均大小为24.4毫米。显微镜下，61.4%的病例以黏液样结构为主。只有5个标本显示高S期细胞分数。所有样本均为DNA二倍体（平均变异系数3.2%）。S期细胞分数与肿瘤大小显著相关（r = 0.73，P = 0.003）。两名复发肿瘤患者在首次切除标本时和第二次手术时均显示高S期细胞分数。
S期细胞分数可能是涎腺多形性腺瘤侵袭性行为的一个有价值的预测指标。高S期细胞分数与更大的肿瘤大小和更高的复发倾向相关。
