6,9-Dihydroxy-3(15)-caryophyllen-4,8-dione--a new antibiotic from a Marasmius species.
作者信息
Fabian K, Anke T, Sterner O
机构信息
Lehrbereich Biotechnologie der Universität, Kaiserslautern, Germany.
出版信息
Z Naturforsch C J Biosci. 1999 Jul-Aug;54(7-8):469-73. doi: 10.1515/znc-1999-7-802.
PMID:10488559
Abstract
6,9-Dihydroxy-3(15)-caryophyllen-4,8-dione (1), a new cytotoxic caryophyllane sesquiterpene, was isolated from fermentations of a tropical Marasmius species. The structure was established by spectroscopic methods. 1 exhibits strong cytotoxic effects on different cell lines, but only weak antimicrobial activities. 1 weakly inhibits the incorporation of leucine and thymidine into proteins and DNA of mammalian cells and interferes with the aggregation of human and bovine platelets.
摘要
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