来自泰国一种菌株深层培养物的胡萝卜烷抗生素金黄铁菌素类似物
Analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a Thai sp.
作者信息
Sandargo Birthe, Kaysan Leon, Teponno Rémy B, Richter Christian, Thongbai Benjarong, Surup Frank, Stadler Marc
机构信息
Microbial Drugs Department, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Technical University of Ilmenau, 98693 Ilmenau, Germany.
出版信息
Beilstein J Org Chem. 2021 Jun 4;17:1385-1391. doi: 10.3762/bjoc.17.97. eCollection 2021.
A recent find of a species in Northern Thailand led to the isolation of five unprecedented derivatives of the carotane antibiotic fulvoferruginin (), fulvoferruginins B-F (-). The structures of these sesquiterpenoids were elucidated using HRESIMS, 1D and 2D NMR, as well as CD spectroscopy. Assessing the bioactivity, fulvoferruginin emerged as a potent cytotoxic agent of potential pharmaceutical interest.
最近在泰国北部发现的一个物种导致了五种前所未有的胡萝卜烷抗生素富铁黄菌素（）的衍生物——富铁黄菌素B - F（-）的分离。这些倍半萜类化合物的结构通过高分辨电喷雾电离质谱（HRESIMS）、一维和二维核磁共振（NMR）以及圆二色光谱（CD）进行了阐明。在评估生物活性时，富铁黄菌素成为了一种具有潜在药学价值的强效细胞毒性剂。
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