Kumar R, Dagher A, Hutchison W D, Lang A E, Lozano A M
Division of Neurology, Faculty of Medicine, University of Toronto, Canada.
Neurology. 1999 Sep 11;53(4):871-4. doi: 10.1212/wnl.53.4.871.
Bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) in a patient with severe idiopathic generalized dystonia resulted in immediate improvement of all aspects of dystonia. During joystick movement, GPi DBS reduced PET activation bilaterally in the primary motor, lateral premotor, supplementary motor, anterior cingulate, and prefrontal areas and ipsilaterally in the lentiform nucleus. Altering basal ganglia function with GPi DBS reverses the overactivity of certain motor cortical areas present in dystonia.
对一名患有严重特发性全身性肌张力障碍的患者进行双侧苍白球内侧部（GPi）深部脑刺激（DBS）后，肌张力障碍的各个方面立即得到改善。在操纵杆运动期间，GPi DBS使双侧初级运动区、外侧运动前区、辅助运动区、前扣带回和前额叶区域以及同侧豆状核的PET激活减少。通过GPi DBS改变基底神经节功能可逆转肌张力障碍中某些运动皮质区域的过度活动。
