Malenka R C, Nicoll R A
Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA.
Science. 1999 Sep 17;285(5435):1870-4. doi: 10.1126/science.285.5435.1870.
Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.
海马体中突触传递的长期增强是学习和记忆可能依赖的突触变化的主要实验模型。本综述介绍了目前对这种突触强度长期增加的分子机制的理解，并描述了一个简单模型，该模型统一了许多以前被认为相互矛盾的数据。
