酒精诱导支气管收缩的哮喘患者对乙醛的气道反应性增加。

Increased airway responsiveness to acetaldehyde in asthmatic subjects with alcohol-induced bronchoconstriction.

作者信息

Fujimura M, Myou S, Kamio Y, Ishiura Y, Iwasa K, Hashimoto T, Matsuda T

机构信息

The Third Dept of Internal Medicine, Kanazawa University School of Medicine, Takara-machi, Japan.

出版信息

Eur Respir J. 1999 Jul;14(1):19-22. doi: 10.1034/j.1399-3003.1999.14a05.x.

DOI:10.1034/j.1399-3003.1999.14a05.x

PMID:10489823

Abstract

Bronchial responsiveness to acetaldehyde, a main factor in alcohol-induced bronchoconstriction, and methacholine were compared between 10 subjects with alcohol-induced bronchoconstriction and 16 asthmatic subjects without alcohol sensitivity. In the alcohol-sensitive group, the geometric mean (geometric SEM (GSEM)) of the provocative concentration of methacholine (PC20,meth) and acetaldehyde (PC20,acet) causing a 20% fall in forced expiratory volume in one second were 0.947 mg x mL(-1) (GSEM 0.139) and 21.0 mg x mL(-1) (GSEM 0.112), respectively, which were not significantly different from those in the nonalcohol-sensitive group, which were 0.634 mg x mL(-1) (GSEM 0.115) and 31.7 mg x mL(-1) (GSEM 0.077), respectively. The ratio of airway responsiveness to acetaldehyde relative to methacholine (log PC20,acet/PC20,meth) was 1.345+/-0.093 (mean+/-SEM) in the alcohol-sensitive group, which was significantly different from the value of 1.699+/-0.059 in the nonalcohol-sensitive group (p=0.0025). A significant correlation was observed between PC20,meth and PC20,acet in both the alcohol-sensitive group (r=-0.742, p=0.0115) and nonsensitive group (r=0.882, p<0.0001). In conclusion, the airways of asthmatic subjects with alcohol-induced bronchoconstriction have a selective hyperresponsiveness to acetaldehyde.

摘要

在10名酒精诱发支气管收缩的受试者和16名无酒精敏感性的哮喘受试者之间，比较了支气管对乙醛（酒精诱发支气管收缩的主要因素）和乙酰甲胆碱的反应性。在酒精敏感组中，使一秒用力呼气量下降20%的乙酰甲胆碱（PC20,meth）和乙醛（PC20,acet）激发浓度的几何平均值（几何标准误（GSEM））分别为0.947mg·mL⁻¹（GSEM 0.139）和21.0mg·mL⁻¹（GSEM 0.112），与非酒精敏感组（分别为0.634mg·mL⁻¹（GSEM 0.115）和31.7mg·mL⁻¹（GSEM 0.077））相比，差异无统计学意义。酒精敏感组中气道对乙醛相对于乙酰甲胆碱的反应性比值（log PC20,acet/PC20,meth）为1.345±0.093（平均值±标准误），与非酒精敏感组的1.699±0.059有显著差异（p = 0.0025）。在酒精敏感组（r = -0.742，p = 0.0115）和非敏感组（r = 0.882，p < 0.0001）中，均观察到PC20,meth与PC20,acet之间存在显著相关性。总之，患有酒精诱发支气管收缩的哮喘受试者气道对乙醛具有选择性高反应性。