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1型糖尿病患者低血糖期间安全驾驶能力的认知

The perception of safe driving ability during hypoglycemia in patients with type 1 diabetes mellitus.

作者信息

Weinger K, Kinsley B T, Levy C J, Bajaj M, Simonson D C, Cox D J, Ryan C M, Jacobson A M

机构信息

Section on Behavioral and Mental Health Research, Joslin Diabetes Center, Boston, Massachusetts 02215, USA.

出版信息

Am J Med. 1999 Sep;107(3):246-53. doi: 10.1016/s0002-9343(99)00221-1.

Abstract

PURPOSE

Insulin-induced hypoglycemia and its sequelae of cognitive impairment may place patients with type 1 diabetes at risk when driving and when making decisions about driving. Little is known about the factors that influence judgments of safe driving ability during hypoglycemia in these patients.

PATIENTS AND METHODS

Thirty men and 30 women with uncomplicated type 1 diabetes (age [mean +/- SD] 33 +/- 9 years, duration 9 +/- 3 years, hemoglobin A1c level 8.7% +/- 1.0%) underwent a stepped hypoglycemic insulin clamp. Serum glucose levels were reduced from 120 mg/dL to 80, 70, 60, 50, and then 40 mg/dL during 190 minutes. At each glucose plateau, patients completed a symptom questionnaire and neuropsychological test, estimated their glucose level, and reported whether they could drive safely.

RESULTS

The proportion of patients judging that they could drive safely decreased as serum glucose levels decreased from 70% at 120 mg/dL to 22% at 40 mg/dL. Men and middle-aged patients were more likely to consider it safe to drive during hypoglycemia than women and those under 25 years of age. Those who were symptomatic and those who recognized hypoglycemia were less likely to report safe driving ability during hypoglycemia. Most patients who were cognitively impaired appeared to recognize this and reported that they could not drive safely at a serum glucose level of 40 mg/dL.

CONCLUSIONS

Adults with type 1 diabetes need educational reinforcement of safe driving habits, particularly to check glucose levels before driving. Glucose levels less than 70 mg/dL should be treated before driving. This information is as important for middle-aged, experienced drivers as it is for younger, inexperienced drivers.

摘要

目的

胰岛素诱发的低血糖及其认知功能损害后遗症可能使1型糖尿病患者在驾驶及做出与驾驶相关决策时面临风险。对于影响这些患者在低血糖期间安全驾驶能力判断的因素,我们知之甚少。

患者与方法

30名男性和30名女性的1型糖尿病患者(年龄[平均±标准差]33±9岁,病程9±3年,糖化血红蛋白水平8.7%±1.0%)接受了逐步低血糖胰岛素钳夹试验。在190分钟内,血清葡萄糖水平从120mg/dL降至80、70、60、50,然后降至40mg/dL。在每个血糖平台期,患者完成一份症状问卷和神经心理学测试,估计自己的血糖水平,并报告是否能够安全驾驶。

结果

随着血清葡萄糖水平从120mg/dL时的70%降至40mg/dL时的22%,判断自己能够安全驾驶的患者比例下降。男性和中年患者比女性及25岁以下患者更有可能认为在低血糖期间驾驶是安全的。有症状的患者以及意识到低血糖的患者在低血糖期间报告自己具备安全驾驶能力的可能性较小。大多数存在认知功能损害的患者似乎认识到这一点,并报告在血清葡萄糖水平为40mg/dL时他们无法安全驾驶。

结论

1型糖尿病成年患者需要加强安全驾驶习惯方面的教育,尤其是在驾驶前检查血糖水平。血糖水平低于70mg/dL时应在驾驶前进行处理。这些信息对于中年、经验丰富的驾驶员和年轻、缺乏经验的驾驶员同样重要。

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