Sato H, Yamada Y, Ishigure N, Nakano T, Enomoto H, Takahashi S, Kubota Y, Inaba J
4th Research Group, National Institute of Radiological Sciences, Chiba, Japan.
J Radiat Res. 1999 Jun;40(2):197-204. doi: 10.1269/jrr.40.197.
Wistar rats inhaled 239PuO2 particles prepared by the calcination of 239Pu hydroxide at 1150 and 400 degrees C. Lung retention, fecal and urinary excretion, and translocation of 239Pu were compared between the two calcination temperatures. The clearance of 239Pu from the lungs was significantly faster in the rats exposed to 239PuO2 calcined at 400 degrees C (low-temperature group) than those exposed to 239PuO2 calcined at 1150 degrees C (high-temperature group). Both the fecal excretion of 239Pu and the ratio of fecal excretion to urinary excretion was greater in the low-temperature group than in high-temperature group. The amounts of 239Pu translocated from the lungs to the other organs were very small. Even in the liver, which accumulated the largest amount of 239Pu except for the lungs, only 0.13-0.20% of the initial lung burden was retained 1 year after inhalation. The amount of 239Pu deposited in the liver was greater in the high-temperature group than in the low-temperature group both at 1 month and 1 year after the inhalation. These findings clearly suggest that the lung retention of 239Pu in rats is significantly affected by the calcination temperature of 239PuO2.
将氢氧化钚在1150℃和400℃下煅烧制备的239PuO2颗粒被Wistar大鼠吸入。比较了两种煅烧温度下239Pu的肺滞留、粪便和尿液排泄以及转移情况。与暴露于在1150℃煅烧的239PuO2（高温组）的大鼠相比，暴露于在400℃煅烧的239PuO2（低温组）的大鼠肺部239Pu的清除速度明显更快。低温组239Pu的粪便排泄量及其粪便排泄与尿液排泄的比率均高于高温组。从肺部转移到其他器官的239Pu量非常少。即使在除肺部外积累239Pu量最大的肝脏中，吸入1年后仅保留了初始肺部负荷的0.13 - 0.20%。吸入后1个月和1年时，高温组肝脏中沉积的239Pu量均高于低温组。这些发现清楚地表明，大鼠肺部239Pu的滞留受到239PuO2煅烧温度的显著影响。
