Morgan A, Black A, Moores S R, Lambert B E
Health Phys. 1986 Apr;50(4):535-9.
This study showed that when SAS/4 mice were exposed to sized 239PuO2 only about 0.5% of the 239Pu was translocated from lung to other organs. The fraction of 239Pu translocated appeared to be independent of the particle size of the administered 239PuO2 within the range of AMADs investigated (0.8-2.2 microns). The distribution of translocated 239Pu was similar to that observed with other species in that most of the activity was associated with the lung-associated lymph nodes followed by bone and liver. The fraction of 239Pu translocated was comparable to that found in studies with rats (ICRP72) but less than that found in more extended studies with beagle dogs.
本研究表明，当SAS/4小鼠暴露于特定大小的239PuO2时，只有约0.5%的239Pu从肺部转移至其他器官。在所研究的空气动力学等效直径（AMAD）范围内（0.8 - 2.2微米），转移的239Pu比例似乎与所给予的239PuO2颗粒大小无关。转移的239Pu分布与在其他物种中观察到的情况相似，即大部分活性与肺相关淋巴结有关，其次是骨骼和肝脏。转移的239Pu比例与大鼠研究（ICRP72）中的结果相当，但低于对小猎犬进行的更广泛研究中的发现。
