Morgan A, Black A, Knight D, Moores S R
Environmental and Medical Sciences Division, Harwell Laboratory, United Kingdom Atomic Energy Authority, Oxfordshire.
Health Phys. 1988 Mar;54(3):301-10. doi: 10.1097/00004032-198803000-00007.
Mice were exposed by inhalation to sized aerosols of 238PuO2 and 239PuO2 which had been fired at temperatures from 550-1250 degrees C and groups killed at times between 1 d and 2 y after exposure. Measurements were made of 238Pu and 239Pu in the lungs, lung-associated lymph nodes, liver and skeleton. With 239Pu, lung retention and translocation were independent of firing temperature. With 238Pu on the other hand, the retention in lung was greater initially than for 239Pu but, with the low-fired oxide, eventually fell below that of 239Pu. With high-fired oxides, the lung retention of 238Pu still exceeded that of 239Pu after 2 y. Translocation to liver and bone was invariably greater for 238Pu than for 239Pu and was also dependent on firing temperature. The practical implications of these findings are discussed.
将小鼠通过吸入方式暴露于在550 - 1250摄氏度温度下烧制的238PuO2和239PuO2的分级气溶胶中，在暴露后1天至2年的不同时间点处死小鼠组。对肺、肺相关淋巴结、肝脏和骨骼中的238Pu和239Pu进行测量。对于239Pu，肺内滞留和转移与烧制温度无关。另一方面，对于238Pu，最初肺内滞留量比239Pu大，但对于低温烧制的氧化物，最终降至239Pu以下。对于高温烧制的氧化物，2年后238Pu在肺内的滞留量仍超过239Pu。238Pu向肝脏和骨骼的转移始终比239Pu大，并且也取决于烧制温度。讨论了这些发现的实际意义。
