Demirkol A, Erdem H, Inan L, Yigit A, Güney M
Medical School of Ankara University, Turkey.
Biol Psychiatry. 1999 Sep 15;46(6):863-7. doi: 10.1016/s0006-3223(99)00087-6.
The neuroanatomic and pathologic basis of Tourette's syndrome or related disorders such as obsessive-compulsive disorder and attention deficit-hyperactivity disorder remains unknown. Although a substantial body of neuroimaging and other data implicate basal ganglia and some point out specifically the globus pallidus in the etiopathogenesis of these three related disorders, no clear or pathologically significant isolated lesions restricted to this region have yet been demonstrated, with the exception of obsessive-compulsive disorder.
A seventeen-year-old male case of Tourette syndrome with comorbid obsessive-compulsive disorder, attention deficit-hyperactivity disorder, stuttering and gait disturbance, who had negative family history is presented.
The patient has failed to respond to drug treatment and his MRI scan revealed bilateral and symmetrical globus pallidus lesions with specific "tiger's eye" appearance of unknown etiology.
Well-localized lesions in the globus pallidus support growing data suggesting the involvement of this brain region in Tourette syndrome and related disorders.
抽动秽语综合征或相关疾病，如强迫症和注意力缺陷多动障碍的神经解剖学和病理学基础仍不清楚。尽管大量的神经影像学和其他数据表明基底神经节与此有关，并且一些研究特别指出苍白球在这三种相关疾病的病因学中起作用，但除了强迫症外，尚未发现局限于该区域的明确的或具有病理意义的孤立性病变。
报告一例17岁男性抽动秽语综合征患者，合并强迫症、注意力缺陷多动障碍、口吃和步态障碍，家族史阴性。
该患者药物治疗无效，其磁共振成像扫描显示双侧苍白球对称病变，具有病因不明的特异性“虎眼”外观。
苍白球中定位良好的病变支持越来越多的数据，表明该脑区参与抽动秽语综合征及相关疾病。
