Castellanos F X, Giedd J N, Hamburger S D, Marsh W L, Rapoport J L
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA.
Neurology. 1996 Dec;47(6):1581-3. doi: 10.1212/wnl.47.6.1581.
Three separate groups, using MRI, have reported basal ganglia abnormalities in Tourette's syndrome (TS). We found similar abnormalities in boys with attention-deficit/hyperactivity disorder (ADHD). Because TS and ADHD are frequently comorbid, we contrasted ADHD boys with and without TS along with control subjects. As expected, we found a significant loss of the normal globus pallidus asymmetry in the patients, but presence or absence of TS did not differentiate the ADHD groups. We conclude that accounting for ADHD comorbidity will be important in future TS morphometric studies.
三个独立的研究小组利用磁共振成像（MRI）报告了抽动秽语综合征（TS）患者基底神经节存在异常。我们在患有注意力缺陷多动障碍（ADHD）的男孩中也发现了类似的异常。由于TS和ADHD经常合并出现，我们将患有和未患有TS的ADHD男孩与对照组进行了对比。不出所料，我们发现患者中正常苍白球不对称性显著丧失，但TS的有无并未区分ADHD组。我们得出结论，在未来的TS形态学研究中，考虑ADHD合并症将很重要。
