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[间歇性常压缺氧期间调节能量稳态的适应性细胞内机制]

[The adaptational intracellular mechanisms regulating energy homeostasis during intermittent normobaric hypoxia].

作者信息

Lebkova N P, Chizhov A Ia, Bobkov Iu I

机构信息

Russian Medical Academy of Postgraduation Education, Moscow, Russia.

出版信息

Ross Fiziol Zh Im I M Sechenova. 1999 Mar;85(3):403-11.

PMID:10494591
Abstract

Rats trained to intermittent normobaric hypoxia (INH) developed an increase of the glycogen contents in the heart and liver parenchymatous cells. Fatty acids seem to be the main source for synthesis of the intracellular glycogen. The intracellular transformation of the lipid energy substrate into the carbohydrates maintains the energy homeostasis in hepatocytes and cardiomyocytes during hypoxic intervals of the INH thus creating the necessary conditions. This kind of regulating the substance supply of the cell energy supports the organism stability under various effects.

摘要

经间歇性常压缺氧(INH)训练的大鼠,其心脏和肝脏实质细胞中的糖原含量增加。脂肪酸似乎是细胞内糖原合成的主要来源。在INH的缺氧间歇期,脂质能量底物在细胞内转化为碳水化合物,维持了肝细胞和心肌细胞的能量稳态,从而创造了必要条件。这种对细胞能量物质供应的调节,在各种作用下支持了机体的稳定性。

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β-Adrenergic signaling in rat heart is similarly affected by continuous and intermittent normobaric hypoxia.大鼠心脏中的β-肾上腺素能信号传导同样受到持续性和间歇性常压缺氧的影响。
Gen Physiol Biophys. 2016 Apr;35(2):165-73. doi: 10.4149/gpb_2015053. Epub 2016 Feb 18.

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