Giordano A, Avantaggiati M L
Department of Pathology, Jefferson Medical College, Philadelphia, Pennsylvania, USA.
J Cell Physiol. 1999 Nov;181(2):218-30. doi: 10.1002/(SICI)1097-4652(199911)181:2<218::AID-JCP4>3.0.CO;2-5.
p300 and CBP are highly related nuclear proteins, which have been implicated in transcriptional responses to disparate extracellular and intracellular signals. There are at least two very good reasons for which p300 and CBP have attracted the attention of the scientific world. First, they belong to an unique class of transcription co-activators possessing histone acetyltransferase activity and therefore have the potential to reveal basic aspects pertaining to regulation of chromatin structure. Second, p300 and CBP deliver essential functions in virtually all known cellular programs, including the decision to grow, to differentiate, or to commit suicide by apoptosis. Consistent with the complexity of these processes, a multitude of intracellular factors physically interact with p300 and CBP. Thus, the task of many investigations has been the understanding of how these proteins receive signals in the cells, what induces their recruitment in a given signal transduction pathway, and what determines the final outcome of their individual activity. This review will focus on mechanistic and theoretical questions pertaining to the mode of action of p300 and CBP posed by works performed in animal and in vitro model systems.
p300和CBP是高度相关的核蛋白，它们参与了对不同细胞外和细胞内信号的转录反应。p300和CBP引起科学界关注至少有两个很好的原因。首先，它们属于一类独特的具有组蛋白乙酰转移酶活性的转录共激活因子，因此有潜力揭示与染色质结构调控有关的基本方面。其次，p300和CBP在几乎所有已知的细胞程序中都发挥着重要作用，包括生长、分化或通过凋亡决定自杀的过程。与这些过程的复杂性相一致，许多细胞内因子与p300和CBP发生物理相互作用。因此，许多研究的任务一直是了解这些蛋白质如何在细胞中接收信号，在给定的信号转导途径中是什么诱导它们被招募，以及是什么决定了它们个体活性的最终结果。本综述将聚焦于在动物和体外模型系统中进行的研究提出的与p300和CBP作用模式相关的机制和理论问题。
