University of California at Berkeley, Berkeley, California 94720, USA.
Howard Hughes Medical Institute, Berkeley, California 94720, USA.
Genes Dev. 2022 Jan 1;36(1-2):7-16. doi: 10.1101/gad.349160.121. Epub 2021 Dec 30.
How distal -regulatory elements (e.g., enhancers) communicate with promoters remains an unresolved question of fundamental importance. Although transcription factors and cofactors are known to mediate this communication, the mechanism by which diffusible molecules relay regulatory information from one position to another along the chromosome is a biophysical puzzle-one that needs to be revisited in light of recent data that cannot easily fit into previous solutions. Here we propose a new model that diverges from the textbook enhancer-promoter looping paradigm and offer a synthesis of the literature to make a case for its plausibility, focusing on the coactivator p300.
远距离调控元件（例如增强子）如何与启动子进行通讯，仍然是一个悬而未决的基本问题。尽管转录因子和辅助因子已被证实可以介导这种通讯，但扩散分子如何将调控信息从染色体上的一个位置传递到另一个位置的机制是一个物理难题——这一问题需要根据最近的数据进行重新审视，因为这些数据很难纳入之前的解决方案。在这里，我们提出了一个有别于教科书上增强子-启动子环化模型的新模型，并对文献进行了综合分析，提出了该模型的合理性，重点介绍了共激活因子 p300。
