降钙素基因相关肽8-37抑制大鼠脊髓背角广动力范围神经元的诱发放电频率。

Calcitonin gene-related peptide 8-37 inhibits the evoked discharge frequency of wide dynamic range neurons in dorsal horn of the spinal cord in rats.

作者信息

Yu L C, Zheng E M, Lundeberg T

机构信息

Department of Physiology, College of Life Science, Peking University, Beijing, People's Republic of China.

出版信息

Regul Pept. 1999 Aug 31;83(1):21-4. doi: 10.1016/s0167-0115(99)00046-4.

DOI:10.1016/s0167-0115(99)00046-4

PMID:10498340

Abstract

The present study was performed to explore the effect of calcitonin gene-related peptide 8-37 (CGRP8-37) on the electrical stimulation-evoked discharge frequency of wide dynamic range (WDR) neurons in the dorsal horn of the spinal cord in rats. The discharge frequencies of WDR neurons were evoked by transdermic electrical stimulation applied on the ipsilateral hindpaw. CGRP8-37 was applied directly on the dorsal surface of the L3 to L5 spinal cord. After the administration of 3 nmol of CGRP8-37, the evoked discharge frequency of WDR neurons decreased significantly, an effect lasting more than 30 min. The results indicate that CGRP receptors play an important role in the transmission of presumed nociceptive information in the dorsal horn of the spinal cord.

摘要

本研究旨在探讨降钙素基因相关肽8 - 37（CGRP8 - 37）对大鼠脊髓背角广动力范围（WDR）神经元电刺激诱发放电频率的影响。通过对同侧后爪进行经皮电刺激来诱发WDR神经元的放电频率。将CGRP8 - 37直接应用于L3至L5脊髓的背表面。给予3 nmol的CGRP8 - 37后，WDR神经元的诱发放电频率显著降低，该效应持续超过30分钟。结果表明，CGRP受体在脊髓背角假定的伤害性信息传递中起重要作用。