Wilke D
Dr. Wilke & Partner Biotech Consulting GmbH, Wennigsen, Germany.
Appl Microbiol Biotechnol. 1999 Aug;52(2):135-45. doi: 10.1007/s002530051500.
Industrial biotechnology has evolved as a significant manufacturing tool for products like fuel-grade ethanol, organic acids and bulk amino acids, but most items are still speciality products for food and pharmaceutical applications. Current development projects within the chemical industry, including lactic acid and 1,3-propanediol based polymers and plastics, indicate that new biotechnological processes and products may soon approach the market place, clearly targeted at the leading petrochemical bulk outlets. This is flanked by a strategic shift by the major chemical companies in to "life sciences"-pharmaceuticals, agrochemicals and the seed business as well as biotech fine chemicals. The recent tremendous achievements in molecular plant genetics and transgenic crop breeding will boost agrobiotechnology, agriculture and renewable raw materials as compelling projects for chemistry and biotechnology. New plant-based production routes may challenge established chemical and biochemical domains, but at the same time open new horizons to valuable feedstocks, intermediates and end-products.
工业生物技术已发展成为一种重要的制造工具，可用于生产燃料级乙醇、有机酸和大宗氨基酸等产品，但大多数产品仍是用于食品和制药应用的特种产品。化学工业目前的开发项目，包括基于乳酸和1,3 - 丙二醇的聚合物及塑料，表明新的生物技术工艺和产品可能很快进入市场，明确瞄准主要的石化大宗产品市场。与此同时，各大化工公司正战略转向“生命科学”——制药、农用化学品、种子业务以及生物技术精细化学品领域。分子植物遗传学和转基因作物育种方面最近取得的巨大成就，将推动农业生物技术、农业和可再生原材料成为化学和生物技术领域引人注目的项目。新的基于植物的生产路线可能会挑战既定的化学和生物化学领域，但同时也为有价值的原料、中间体和最终产品开辟了新的前景。
